Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
نویسندگان
چکیده
Tumor stage, age of patient, and amplification of MYCN predict disease outcome in neuroblastoma. To gain insight into the underlying molecular pathways, we have obtained expression profiles from 94 primary neuroblastoma specimens. Advanced tumor stages show a characteristic expression profile that includes downregulation of multiple genes involved in signal transduction through Fyn and the actin cytoskeleton. High expression of Fyn and high Fyn kinase activity are restricted to low-stage tumors. In culture, expression of active Fyn kinase induces differentiation and growth arrest of neuroblastoma cells. Expression of Fyn predicts long-term survival independently of MYCN amplification. Amplification of MYCN correlates with deregulation of a distinct set of genes, many of which are target genes of Myc. Our data demonstrate a causal role for Fyn kinase in the genesis of neuroblastoma.
منابع مشابه
Using Gene Expression Profiling and Artificial Neural Networks for Patients with Neuroblastoma
EP 1683 862 A1 T 2006 Khan et al., “Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks', Nature Medicine, 7(6):673-679 (2001). Barrett et al., “Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expression'. Drug Discovery Today, 8(3): 134-141 (2003). Berwanger et al., “Loss of a FYN-regulated Differentiatio...
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ورودعنوان ژورنال:
- Cancer cell
دوره 2 5 شماره
صفحات -
تاریخ انتشار 2002